Abstract
An air‐stable liquid trifluoromethylating reagent is readily synthesized from gaseous hexafluoroacetone and 2‐methylproline on a gram scale. The reaction of the trifluoromethylating reagent with tert‐butoxy cuprate K[Cu(OtBu)2] leads to the CuCF3 in high yield. This species is directly formed from the tetrahedral cuprate intermediate through intramolecular migration of the trifluoromethyl group to copper. The CuCF3 reagent prepared in situ by our method can be used for the trifluoromethylation of aryl iodides, arylboronic acids, and terminal alkynes in good to excellent yields, even on a gram scale. Furthermore, the CuC2F5 reagent can be prepared in the same way, and this can be used in the pentafluoroethylation of arylboronic acids or aryl bromides in good to excellent yields.
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