Abstract
Mean blood pressure increase was produced by : (1) renal constriction polus contralateral nephrectomy, and (2) cadmium acetate ingestion. Blood pressure was measured directly via the middle ear artery. Cyclic nucleotide levels were determiend by 125I-radioimmunoassay. Levels of cAMP were reduced in both hypertensive subgroups when compared to controls. The altered cAMP levels suggest a relationship of this nucleotide to the maintenance of increased blood pressure.
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