Abstract
AbstractAn efficient access to a novel series of organophosphorus compounds with a cyclosulfamide moiety is described. Starting from α‐hydroxyphosphonates, the 2‐chloroethyl‐(1, 2, 5‐ thiadiazoline‐2‐carbonyloxy‐1‐ dioxide) phosphonates compounds were prepared in three steps including an Abramov reaction, carbamoylation‐sulfamoylation with chlorosulfonyl isocyanate and an intramolecular cyclisation. The spectroscopic methods (1H NMR, 13C NMR, 31P NMR, MS and IR) were used to determine the structural characteristics of the synthesized compounds and X‐ray crystallographic data were provided for compound 3c. Some selected compounds were screened in vitro for their antimicrobial activity against a panel of microorganisms, resulting in a good antibacterial activity compared to standard drugs.
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