Abstract
Digital microfluidics is transforming microbiology research by providing new opportunities for high-throughput sample preparation and point-of-care diagnostics. Over the past decade, several design-automation (synthesis) techniques have been developed for on-chip droplet manipulation. However, these methods oversimplify the dynamics of biomolecular protocols and they have yet to make a significant impact in biochemistry/microbiology research, leading to a large gap between advances in biochip design and the adoption of biochips for running biomolecular protocols. In this paper, we bridge this gap by introducing a new paradigm for biochip design automation. By exploiting advances in the integration of sensing systems into a digital-microfluidic biochip, we present a number of synthesis solutions that use realistic models of biomolecular protocols to address real-world microbiology applications through cyber-physical adaptation. This paper also details a vision for continued research on design-automation and optimization methodologies for the realization of biomolecular protocols using microfluidic biochips.
Accepted Version
Published Version
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