Abstract
This chapter focuses on cutaneous vascular immunofluorescence (IF). Direct IF procedures have been used for more than a decade in research and as a clinical diagnostic technique for the investigation of vasculitis. In a study described in the chapter, the overall sensitivity of positive vascular immune deposits in rheumatoid vasculitis, necrotizing vasculitis, and livedoid vasculitis varied from 76%–81%. Cutaneous vascular immune deposits have been reported in many of the recognized vasculitides. The specificity of vascular immune deposits is also increased by the definitive vessel morphology which is found by direct IF. The location of vessels with immune deposits is also helpful in assessing their significance.
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