Abstract
The present study was designed to evaluate the biological potential of Cuscuta reflexa and Carthamus oxyacantha. The ethanolic crude extract (C. reflexa; 9.1% and C. oxyacantha; 10.4%) was partitioned with different solvents at pH 3.0, 9.0 and 7.0. Phytochemical study showed that n-hexane fractions were rich source of terpenoids and ethyl acetate fractions were phenolic in nature while chloroform fractions contained alkaloidal skeleton. Total phenols were calculated with FC method and ranged 3.5 to 71.4 mg GAE/100 g DW. Antioxidant (DPPH & FRAP), enzyme inhibition potential (Protease & AChE) and antimicrobial activities were examined by the standard protocols. It was observed that about all extracts exhibited significant DPPH activity range (IC50 09 ± 0.5 to 62 ± 1.2 μg/ml). The DPPH active extracts/fractions also showed remarkable reducing potential. A strong correlation has been found between phenolics and antioxidant activities. Antimicrobial assay that was performed against four microbes and results revealed that FMC-6 and FMP-8 were active against all the tested microbes, while FMP-2 was inactive. Eight extracts/fractions of these plants expressed more than 50% inhibition of the targeted enzymes.
Highlights
The nature’s garden of medicine is being exposed since ancient civilization era
It is found in Pakistan, India, China, eastern Asia and Afghanistan C. reflexa is used as constituent of many medical compositions, which are effective in the treatment of headache, itching, migraine, chronic catarrh, amnesia, epilepsy, expectorates, prolong fever and constipation
Carthamus oxyacantha belongs to family Asteraceae found in Pakistan, Afghanistan, India, Iran, Azerbaijan, Iraq and Kyrgyzstan
Summary
Still more than three fourth (3/4) of the world population depends on medicinal plants or their extracts for life sustaining process. As these are capable to assuage and treat human ailments and infirmity. Belongs to family Cuscutaceae alternate Convolvulaceae commonly known as akasbail or amarwala It is found in Pakistan, India, China, eastern Asia and Afghanistan C. reflexa is used as constituent of many medical compositions, which are effective in the treatment of headache, itching, migraine, chronic catarrh, amnesia, epilepsy, expectorates, prolong fever and constipation. Seeds and flowers have compounds like glycosides, serotonin, flavonoids, and sterols (Souri et al 2004; Hassan et al 2010)
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