Abstract

Design Of Therapeutic MABS.- CDR Repair: A Novel Approach to Antibody Humanization.- Nanobodies, Single-Domain Antigen-Binding Fragments of Camelid Heavy-Chain Antibodies.- Expression and Production of MABS.- GPEx(R) A Flexible Method for the Rapid Generation of Stable, High Expressing, Antibody Producing Mammalian Cell Lines.- Advancing Our Cell Culture Platform: Incorporating Lessons Learned and New Technologies.- Recovery and Purification.- Addressing Changes Associated with Technology Transfer: A Case Study.- Concepts for Disposables in Biopharmaceutical Manufacture.- Formulation and Delivery.- Formulation and Delivery Issues for Monoclonal Antibody Therapeutics.- Challenges in the Development of High Protein Concentration Formulations.- Protein Immobilization by Crystallization and Precipitation: An Alternative to Lyophilization.- Analytics and Specification Setting for MABS.- Characterizing High Affinity Antigen/Antibody Complexes by Kinetic and Equilibrium Based Methods.- Analytical Characterization of Monoclonal Antibodies: Linking Structure to Function.- Analysis of Irreversible Aggregation, Reversible Self-association and Fragmentation of Monoclonal Antibodies by Analytical Ultracentrifugation.- Biophysical Signatures of Monoclonal Antibodies.- Pharmacokinetics and Immunogenicity.- Impact of Fc Glycosylation on Monoclonal Antibody Effector Functions and Degradation by Proteases.- Immunogenicity Assessment of Antibody Therapeutics.- Armed Antibodies and New Classes of Antibodies.- Production of Monoclonal Antibodies in E. coli.- Recent Advancements in the Use of Antibody Drug Conjugates for Cancer Therapy.- Antibody Radiolabeling.

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