Abstract
Recent advances in Cancer diagnostics are adding newer insights every day. An extensive review of existing technologies enabling the non-invasive sampling of circulating tumor cells (CTCs) in peripheral blood aptly named as liquid biopsy is presented in this article. The significance of detecting the presence of CTCs which is one of the main objectives of liquid biopsy and their biological implications are described. Various approaches of liquid biopsy such as CTC characterization methods, technical challenges, molecular characterization of captured cancer cells, mechanisms to study these cells and downstream proteomic applications are explored with an emphasis on single cell proteome applications. Examples from recently published works are discussed to highlight the advantages and limitations of the different techniques. We summarize the vast scope and value of the wider implementation of CTCs as a cancer theranostic tool especially to monitor treatment response to targeted cancer therapeutic agents. Finally, a perspective on the future trends and promising research directions in this field are proposed.
Published Version
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