Abstract
[8] But the study conducted by Aso et al[9] did not find significant difference in mortality during hospitalization between patients with and those without cyclosporine A As for tacrolimus, a study showed that patients who received glucocorticoids and tacrolimus not only had improved survival rate and duration, but also had reduced AE recurrence, in comparison with patients who received glucocorticoids alone [14] It was retrospective, and a RCT (NCT03584802) was sponsored by Assistance Publique-Hopitaux de Paris to evaluate the efficacy and safety of glucocorticoids combined with plasma exchanges, rituximab, and IVIG vs standard glucocorticoid therapy in patients admitted in intensive care unit with severe AE-IPF Because of the coronavirus disease 2019 epidemics, the study has been suspended [19] Extracorporeal membrane oxygenation (ECMO) is now regarded as a lifesaving option for patients who are candidates for lung transplantation, because it is unable to reverse the progression of interstitial lung disease and acute respiratory failure
Published Version
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