Abstract
The severe acute respiratory syndrome virus (SARS-CoV-2), a novel coronavirus first discovered in Wuhan, China in December 2019 causes the Coronavirus Disease 19 (COVID-19), which presents with a wide range of clinical symptoms from mild or moderate to severe and critical illnesses. With the continuing transmission of the virus worldwide and the rapidly evolving situation globally, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic in March. Currently, there is no proven specific treatment for this potentially deadly disease beyond supportive care. However, a massive effort has been put globally into the investigation of medications and other interventional measures to fight COVID-19. Convalescent plasma therapy from recovered patients has recently drawn considerable interest. Several alternative medical treatments, although evidence of their efficacy still lacking, have also gained popularity, especially in countries with such traditions such as India and China. Rapid repurposing of drugs for COVID-19 has revealed a few promising candidate antiviral agents, but further research, especially high quality randomized controlled trials, will be needed to prove their efficacy and safety in the clinical use to treat COVID-19. Vaccine development has been the imperative task in the battle against SARS-CoV-2. While clinical trials have been launched for several candidate vaccines, research on COVID-19 vaccines is still at an early stage. So far, optimized supportive care remains the best practice against COVID-19.
Highlights
The Severe acute respiratory syndrome virus (SARS-CoV-2), initially named as 2019 novel coronavirus (2019-nCoV), is a novel strain of zoonotic coronavirus that was first discovered in Wuhan, China, where a cluster of pneumonia cases was first reported in December 20191
The severe acute respiratory syndrome virus (SARS-CoV-2), a novel coronavirus first discovered in Wuhan, China in December 2019 causes the Coronavirus Disease 19 (COVID-19), which presents with a wide range of clinical symptoms from mild or moderate to severe and critical illnesses
In this article, we presented a brief overview of the clinical practice in treating COVID-19, the clinical trials for new pharmaceutical options, as well as the current status of vaccine development for SARS-CoV-2
Summary
Current Status of Treatment Options, Clinical Trials, and Vaccine Development for SARS-CoV-2 Infection. Ran Jing[1 ], Rama Rao Vunnam[2 ], Yuhong Yang[1 ], Adam Karevoll[1 ] and Srinivas Rao Vunnam1*
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