Abstract
Emergence of large-scale plague outbreaks in Africa and South America countries in the modern period, characterized by high frequency of pneumonic plague development (including with lethal outcome) keeps up the interest of scientists to the matters of development and testing of means for specific prophylaxis of this particularly dangerous infectious disease. WHO workshop that was held in 2018 identified the general principles of optimization of design and testing of new-generation vaccines effectively protecting the population from plague infection. Application of the achievements of biological and medical sciences for outlining rational strategy for construction of immunobiological preparations led to a certain progress in the creation of not only sub-unit vaccines based on recombinant antigens, but also live and vector preparations on the platform of safe bacterial strains and replicating and non-replicating viruses in recent years. The review comprehensively considers the relevant trends in vaccine construction for plague prevention, describes advantages of the state-of-the art methodologies for their safety and efficiency enhancement.
Highlights
that was held in 2018 identified the general principles of optimization
of design and testing of new-generation vaccines effectively protecting the population from plague infection
medical sciences for outlining rational strategy for construction of immunobiological preparations led to a certain progress in the creation
Summary
В качестве основы для создания прототипов живых мукозальных вакцин против чумы используют аттенуированные штаммы Y. pseudotuberculosis и Salmonella typhimurium. Иммунизация мышей прототипом вакцины rAd5YFV обеспечивала 100 % защиту против бубонной и легочной чумы при парентеральном или интраназальном заражении дозой 4,62⋅105 КОЕ вирулентного штамма Y. pestis СО92.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
