Abstract
Biomarkers are the main focus of current researches in biological characteristics that are easily measured in patients, and their discovery has laid the foundation for personalized medicine. Salivaomics and metabolomics are the rapidly emerging diagnostics focused on comprehensive profiling of metabolites in intracellular or biofluid sample. A systematic search of PubMed Central, Ebsco Host, Science Direct, and Scopus was done and the search terms included salivaomics, metabolomics, biomarkers, metabolites, oral cancer, proteomics, personalized medicine, and omics. This review article summarizes on the significance of salivary metabolites as diagnostic and prognostic biomarkers due to different biochemical pathways in oral cancer patients and healthy controls, even early detection of cancer in patients, thus emphasizing on the rigorous need of future research in this field.
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