Abstract
Current questions and controversies in chromosome fragile site research: does WWOX , the gene product of common fragile site FRA16D, have a passive or active role in cancer?
Highlights
One such example of a tumor suppressor gene is the WW domain-containing oxidoreductase (WWOX), which spans the common fragile site (CFS) FRA16D
Tumor-suppressing functions of WWOX identify it as a master regulator that protects from genomic instability
We propose that WWOX loss early in the precancerous stage is not a secondary/passive event because of the fragility of its locus but provides a growth advantage that actively contributes to tumorigenesis
Summary
One such example of a tumor suppressor gene is the WW domain-containing oxidoreductase (WWOX), which spans the CFS FRA16D. Current questions and controversies in chromosome fragile site research: does WWOX, the gene product of common fragile site FRA16D, have a passive or active role in cancer? ● The controversy about common fragile site (CFS) and their associated genes/products is whether their aberrations in cancer passively accumulate or actively contribute to cancer development.
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