Abstract
Complex interfaces have evolved at the junction between tissues of the musculoskeletal system to overcome the problems of impedance mismatch. In this review, we have revisited the anatomy, development, injury and repair of the interface between bone and tendon/ligament, also known as the osteotendinous/osteoligamentous junction or enthesis. Specifically, the existing options for repair have also been discussed along with the current progress of interfacial tissue engineers aiming to manufacture multiphase tissue constructs for repair of these complex interfaces in vitro.
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