Current evidences of therapeutic effects of sulforaphane on oral and intestinal microbiota in Autism Spectrum Disorder – ASD

Abstract

Growing evidence suggests that the Sulforaphane promising agent against oxidative stress related to Autism Spectrum Disorder (ASD), can reduce signs and symptoms like impaired communication and socialization, stereotyped behaviour and neurodevelopmental abnormalities. The oral and intestinal microbiota is extremely important, when out of balance, is one of the main causes of various desordens in the human organism. Broccoli is one of the functional foods most investigated by science. It contains Sulforaphane, an isothiocyanate with great antioxidant and anti-inflammatory capacity; with studies focusing on neurodegenerative and neurodevelopmental diseases. The bibliographic survey was carried out on the Pubmed platform, between 2013 and 2023, in informations provided for Ministério da Saúde – Brasil and in nutrition books. This is a systematic review on Sulforaphane supplementation for people with ASD and its implications for controlling the symptoms that most affect this population, opens a new avenue for managing autistic patients through non-pharmacological intervention.