Current common prodrug delivery methods and biochemical property

Abstract

Prodrugs are pivotal in overcoming drug delivery and absorption challenges. These bioreversible derivatives are strategically designed to address medicines poor bioavailability and administration constraints. Prodrugs offer versatile solutions for various delivery methods, including oral, dermal, nasal, and central nervous system (CNS) routes and tumor targeting. This literature review aims to summarize several prodrugs delivery methods. The report also focuses on the common concepts of prodrug design. The utilization of prodrugs also includes innovative strategies, such as receptor-mediated internalization and responsive drug release, demonstrating promising outcomes for cancer therapy. The application of prodrug methods is comprehensive. Prodrugs emerged as a universal approach to improve drug administration and absorption, with their applications spanning diverse medical contexts. By tailoring prodrugs to specific delivery routes and addressing unique challenges, researchers open avenues for more effective and targeted therapies. Further exploration and optimization of prodrug strategies hold the potential to revolutionize drug delivery in clinical settings. Although prodrugs have many advantages, there are still many possible future improvements. Many diseases or target organs still need help applying prodrugs even though the current drug design needs this technology for administration. Future research should focus on the lack of chemical stability, including considering the balance between aqueous solubility and lipophilicity. Also, the elimination of the formation of degradation by-products or the design of acceptable metabolism pathways is another aspect that should be considered.