Abstract
Abstract Diabetic nephropathy (DN) is a chronic kidney disease that occurs in patients with diabetic mellitus. In the United States of America, one in three people with diabetes suffers from DN. Globally, DN occurs in 30%–40% of patients diagnosed with diabetes. Circular ribonucleic acids (circRNAs) are non-coding, closed-loop RNAs that play critical roles in regulating gene expression by sponging microRNAs (miRNAs). Recent studies have implicated circRNAs in the regulation of various diseases including DN. We delineate circRNA biological networks from the evidence gleaned from clinical studies. Further, we elucidate circRNA-associated signal transduction pathways in the pathogenesis of DN. Taken together, this will facilitate the discovery of novel circRNA and/or miRNA biomarkers for diagnostic and/or therapeutic intervention in DN.
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