Abstract
Regulation of cell behavior in response to nanoscale features has been the focus of much research in recent years and the successful generation of nanoscale features capable of mimicking the natural nanoscale interface has been of great interest in the field of biomaterials research. In this review, we discuss relevant nanofabrication techniques and how they are combined with bioengineering applications to mimic the natural extracellular matrix (ECM) and create valuable nanoscale interfaces.
Highlights
Cell behavior is regulated by soluble factors, cell–cell interactions and cell–extracellular matrix (ECM) interactions
Despite soluble chemical-based regulation of cell behavior traditionally being a topic of great interest, many researchers are focusing on regulating cell behavior using physical cues associated with the nanoscale features of the ECM
As the interest in regulating nanoscale features and the nanoscale interfaces arising from these features has heightened, a range of nanofabrication techniques have been developed and used in the generation of physical cues capable of enhancing key characteristics of stem cells, such as their ability to differentiate down particular lineages
Summary
Current approaches for modulation of the nanoscale interface in the regulation of cell behavior. Hannah Donnelly, BSca,[1], Matthew J Dalby, PhDa, Manuel Salmeron-Sanchez, PhDb, Paula E Sweeten, BSca,⁎,1. ACentre for Cell Engineering, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, Scotland, UK bBiomedical Engineering Research Division, University of Glasgow, Glasgow, Scotland, UK Received 23 November 2016; accepted 9 March 2017
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