Abstract
In plant soft-rotting bacteria Pectobacterium, quorum sensing (QS) regulates the secretion of an arsenal of plant cell wall degrading extracellular enzymes (PCWDEs) and flagella-mediated motility via two different signaling molecules such as 3-oxohexanoyl-L-homoserine lactone (3-oxo-C6-AHL) and 3-oxooctanoyl-L-homoserine lactone (3-oxo- C8-AHL). In the present investigation, the phytochemical compound curcumin was assessed for its QS inhibitory potential against AHL-dependent PCWDEs production and motility in P. wasabiae SCC3193, P. carotovorum subsp. Carotovorum Pcc21 and P. carotovorum subsp. Carotovorum Pcc. Interestingly, curcumin at sub-MIC effectively inhibited the production of PCWDEs as well as the swimming and swarming motility of all tested pathogens in a non-bactericidal fashion. Subsequently, the in vitro root pathogenicity assay in Arabidopsis thaliana unveiled the rescuing efficacy of curcumin against the pathogenicity of tested plant pathogens by attenuating its QS mediated virulence factors production. Besides, studies with QS mutant strain Pcc21-M10 also evidenced the QSI property of curcumin.
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