Curative effect of octreotide in the treatment of the intestine harm induced by pancreatitis associated ascetic fluid

Abstract

Objective To investigate the curative effect of octyeotide in the treatment of the intes tine harm induced by pancreatitis associated ascetic fluid (PAAF) in rats. Methods Forty-eight healthy Sprague-Dawwley (SD) rats were randomly divided into three groups:blank group (A) ,model group (B) and octreotide treatment group (C). PAAF was intraperitoneally injected in groups B and C,and octreotide was given in group C. The levels of serum lipopolysaccharides (LPS) and tumor necrosis factor a (TNF-α) were determined, and those of ATP enzyme and TNF-α were measured in intestinal tissues. The pathological changes of intestinal mucosa were observed. Results Except that the activity of ATP was decreased (P < 0.05) ,the indexes above were all increased (P<0.05) in group A as compared with group B (P<0.05). Except that the activity of ATP enzyme was greatly increased (P <0.05) ,all the other indexes were obviously de creased in group C as compared with group B (P <0.05). Conclusion Octreotide can alleviate the the intes tine harm induced by PAAF. Key words: Pancreatitis; Ascetic fluid; Iintestines; Endotoxin; Octreotide