Abstract
Objective To observe the efficacy and action mechanism of ulinastatin (UTI) combined with octreotide in the treatment of acute pancreatitis. Methods 96 cases of acute pancreatitis were divided into the group A (UTI and octreotide,n=48) and the group B (octreotide,n=48) according to the random number table method. The levels of serum inflammatory factors [interleukin -8 (IL-8), tumor necrosis factorα(TNF-α), interleukin -6 (IL-6)] and the blood rheology indexes (plasma viscosity, platelet adhesion rate, high shearing of whole blood viscosity) were measured before treatment (T1) and after 2 weeks of treatment (T2), and the efficacy was evaluated at T2. Results The total effective rate in the group A was higher than that in the group B (95.83% vs.81.25%;χ2=5.031,P=0.025). At T2, the levels of serum IL-8, TNF-α, IL-6 in the two groups [(26.63±5.49), (34.53±6.51), (24.63±8.21), (31.48±9.27), (22.04±4.27), (29.56±5.51) ng/L] were lower than those at T1 [(48.21±7.19), (49.19±7.85), (61.26±11.36), (60.84±10.92), (41.59±6.63), (40.57±5.75) ng/L] (t=16.527, 9.959, 18.106, 14.201, 17.175, 9.578;P<0.05), those in the group A were lower than those in the group B (t=6.427, 3.833, 7.474;P<0.05). At T2, plasma viscosity, platelet adhesion rate, high shearing of whole blood viscosity in the two groups [(1.76±0.13)%, (1.94±0.22)%, (36.54±6.51)%, (49.78±8.47)%, (5.24±0.77), (5.79±0.91) map/s] were lower than those at T1 [(2.15±0.36)%, (2.16±0.37)%, (81.35±13.46)%, (81.36±13.48)%, (6.28±1.18), (6.27±1.16) map/s] (t=7.059, 3.541, 20.764, 13.743, 5.144, 2.256;P<0.05), those in the group A were lower than those in the group B (t=4.880, 8.580, 3.197;P<0.05). Conclusion UTI combined with octreotide in the treatment of acute pancreatitis can significantly improve the efficacy, reduce inflammatory reaction, and improve the blood microcirculation, and it is favorable for prognosis of the disease. Key words: Ulinastatin; Octreotide; Acute pancreatitis; Action mechanism
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