Curative effect of Bronchoscopy lavage for bronchiectasis complicated with infection

Abstract

Objective To investigate the curative effect of bronchoscopy lavage for bronchiectasis complicated with infection. Methods Total of 126 cases of bronchiectasis complicated with infection were selected as the study subjects from July 2016 to December 2017 in our hospital, and were divided into observation group and control group according to the random number method (63 cases in each group). Patients in the control group were treated with routine internal medicine such as anti-infection, postural drainage and balanced electrolyte. On the basis of routine treatment, patients in the observation group were given a combination of local injection therapy with the Olympus BF-260 electron fiber bronchoscopic bronchial pulmonary alveolar lavage. The clinical symptoms and signs (thermal annealing time, cough and expectoration vanished, then disappeared time, the length of time), arterial blood gas indexex (PaO2, PaCO2, SaO2, FiO2), immune function indexex (IgA, IgG, IgM, CD4+/CD8+), inflammatory factor indexes (CRP, TNF-α, IL-6) and curative effects (significant effect, effect and invalid) were compared between patients in the two group, respectively. Results The time of heat retreat, coughing and phlegm disappearence, hospitalization, rale disappearance of patients in the observation group were (4.22 ± 1.12) d, (6.17 ± 0.59) d, (7.12 ± 4.05) d and (10.2 ± 2.7) d, while those were (5.83 ± 0.72) d, (11.29 ± 0.85) d, (10.29 ± 3.12) d and (11.9 ± 3.2) d in the control group, with significant differences (t = 9.578, 39.276, 4.922, 3.223; all P < 0.001). The arterial blood gas indexes (PaO2, PaCO2, SaO2, FiO2) of patients in the observation group were significantly better than those of the control group, with significant differences (t = 4.044, 19.090, 6.329, 5.477; all P < 0.001). The immune function indexes (IgA, IgG, IgM, CD4+/CD8+) of the patients in the observation group were better than those in the control group, with significant differences (t = 4.433, 6.667, 3.577, 5.416, all P < 0.001). The inflammatory control effect of patients in the study group was better than that in the control group, with significant difference (P < 0.001). The effective rate of treatment in the observation group (74.6%) was better than that of the control group (47.6%), with significant difference (χ2 = 9.651, P = 0.002). Conclusions In the treatment of bronchiectasis and infection, compared with conservative treatment, bronchial lavage could improve the clinical symptoms and signs, correct the inappropriate blood gas indexes, reduce the levels of serum inflammatory factors, and improve the levels of serum immune cells and improve the efficiency, with significant advantages. Key words: Bronchoscope lavage; Bronchiectasis; Infection; Clinical observation