Curative effect of benidipine hydrochloride on patients with coronary slow flow angina pectoris

Abstract

Objective To investigate the curative effect of benidipine hydrochloride on patients with coronary slow flow angina pectoris(CSFA). Methods Sixty cases patients with CSFA were randomly divided into two groups of 30 patients each.In the control group patients were received aspirin(100 mg, 1 times/d) and atorvastatin(20 mg, 1 times/d) as basic treatment; in the treatment group patients were received basic treatment plus benidipine hydrochloride(4 mg, 1 times/d). Follow up for 6 mouths, the effectiveness rate of treatment(relief of angina and electrocardiogram of myocardial ischemia), the correction of thrombolysis in myocardial infarction(TIMI) frame count(CTFC) before and after the different intervention, and the incidence of adverse cardiovascular events were compared between the treatment group and the control group. Results The effectiveness rate of treatment in the treatment group(86.7%, 26/30) was significantly higher than that in the control group(63.3%(19/30); χ2=4.356, P=0.037). There were significant reductions of CTFC in both groups after the different intervention(treatment group: (28.43±3.95) frames vs.(18.40±3.73) frames, t=10.254, P=0.000; control group: (27.87±4.14) frames vs.(21.87±4.17) frames, t=5.580, P=0.000). There was more significant reductions of CTFC in the treatment group as compared to the control group(t=2.138, P=0.037). The incidence of adverse cardiovascular events in the treatment group(10.0%(3/30)) was significantly lower than that in the control group(33.3%(10/30), P=0.028). Conclusion Benidipine hydrochloride is effective in the treatment of CSFA. Key words: Benidipine hydrochloride; Coronary slow flow; Angina pectoris; Curative effect