Abstract
IntroductionCurare is one of the best-examined neurotoxins of the world, which has empirically been used for centuries by American Indigenes. Research on curare has been performed much later, a global scientometric analysis on curare research or its derivates does not yet exist. This bibliometric analysis is part of the global NewQis-project and should illuminate both toxic and historic issues of research on curare.MethodsThe ISI Web of Science was searched for data covering 1900 to 2013 using a term which included as many original articles on curare as possible. 3,867 articles were found and analyzed for common bibliometric items such as the number of citations, language of the articles or the (modified) Hirsch-Index (h-index). Results are illustrated utilizing modern density equalizing map projections (DEMP) or beam diagrams.ResultsMost publications were located in North America and Europe. The USA has the highest number of publications as well as the highest h-index. The number of publications overall rose until the late 1990s and later decreased. Furthermore, sudden increases of research activity are ascribable to historic events, like the first use of curare as muscle relaxant during surgery.DiscussionThis scientometric analysis of curare research reflects several tendencies as previously seen in other bibliometric investigations, i.e. the scientific quality standard of North America and Europe. Research on curare decreased however, due to the declining attention towards this muscle relaxant. This work exemplifies also how scientometric methods can be used to illuminate historic circumstances immediately stimulating scientific research.
Highlights
Curare is one of the best-examined neurotoxins of the world, which has empirically been used for centuries by American Indigenes
The results illustrate the development of scientific research activity of this neurotoxin over the decades; on the other hand we address the shift in research focus
This study evaluates and illustrates the scientific research of curare and its derivates from 1900 to 2013
Summary
Curare is one of the best-examined neurotoxins of the world, which has empirically been used for centuries by American Indigenes. Research on curare has been performed much later, a global scientometric analysis on curare research or its derivates does not yet exist This bibliometric analysis is part of the global NewQis-project and should illuminate both toxic and historic issues of research on curare. Curare is used for centuries by humans, and its toxic pathomechanism [1] has been meticulously examined. This insidious neurotoxin has killed many humans and animals over the centuries. Struck by the poisoned weapons, died within a few minutes. It was just a question of time, until the underlying molecular mechanism aroused interest in European scientists as well as physicians [2,3,4,5]
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