Abstract
Background: The management of various central nervous system (CNS) disorders has been challenging, due to highly compact blood-brain barrier (BBB) impedes the access of most pharmacological agents to the brain. Among multiple strategies proposed to circumvent this challenge, intranasal delivery route has sparked great interest for brain targeting in the past decades. The aim of this study was to apply scientometric method to estimate the current status and future trends of the field from a holistic perspective. Methods: All relevant publications during 1998–2020 were retrieved from the Web of Science Core Collection (SCIE, 1998-present). Two different scientometric software including VOS viewer and CiteSpace, and one online platform were used to conduct co-authorship, co-citation, and co-occurrence analysis of journals, countries, institutes, authors, references and keywords. Results: A total of 2,928 documents, including 2,456 original articles and 472 reviews, were retrieved. Our analysis revealed a significant increasing trend in the total number of scientific publications over the past 2 decades (R 2 = 0.98). The United States dominated the field, reflecting in the largest amount of publications (971), the highest H-index (99), and extensive international collaboration. Jamia Hamdard contributed to most publications. Frey WH and Illum L were key researchers with the highest number of publications and citations, respectively. The International Journal of Pharmaceutics was the most influential academic journal, and Pharmacology/Pharmacy and Neurosciences/Neurology were the hottest research categories in this field. Based on keywords occurrence analysis, four main topics were identified, and the current research focus of this field has shifted from cluster 4 (pathways and mechanisms of intranasal delivery) to cluster 2 (the study of nasal drug delivery systems), especially the nanostructured and nano-sized carrier systems. Keywords burst detection revealed that the research focus on oxidative stress, drug delivery, neuroinflammation, nanostructured lipid carrier, and formulation deserves our continued attention. Conclusion: To the authors’ knowledge, this is the first scientometric analysis regarding intranasal delivery research. This study has demonstrated a comprehensive knowledge map, development landscape and future directions of intranasal delivery research, which provides a practical and valuable reference for scholars and policymakers in this field.
Highlights
Central nervous system (CNS) disorders, including neurodegenerative, neoplastic, and neuropsychiatric disorders are becoming increasingly prevalent around the world due to rapidly aging populations (Hebert et al, 2013)
Similar to the results described above, the evolution of the burst keywords during the past decade shows that the research focus has experienced a transition from the study of pathways and mechanisms of intranasal delivery to the study of intranasal drug delivery for CNS disorders and nasal drug delivery systems
This study provides a comprehensive overview of the knowledge framework, global trends and hotspots in the field of intranasal delivery research over the past 2 decades by using the scientific method of scientometric and visualized analysis
Summary
Central nervous system (CNS) disorders, including neurodegenerative, neoplastic, and neuropsychiatric disorders are becoming increasingly prevalent around the world due to rapidly aging populations (Hebert et al, 2013). Numerous studies have proposed promising strategies to improve the delivery of therapeutic agents to the brain by circumventing or overcoming the BBB during the last decades. These strategies include intracerebroventricular injections (Lopachev et al, 2019), convection enhanced delivery (Zhan and Wang, 2018), inhibition of efflux transporters (Sanchez-Covarrubias et al, 2014), chemical modification (Al-Ahmady, 2018), and the application of hyperosmotic agents (Patel et al, 2009) or focused ultrasound (Dauba et al, 2020; Lin et al, 2020; Wu et al, 2021a), and so on. The aim of this study was to apply scientometric method to estimate the current status and future trends of the field from a holistic perspective
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