Abstract
BackgroundThe purpose of this meta-analysis was to evaluate the diagnostic accuracy of periprosthetic tissue culture in blood culture bottles (BCB) for periprosthetic joint infection (PJI).MethodsPubMed, Web of Science, and Embase were systematically searched for eligible studies evaluating the diagnostic performance of periprosthetic tissue culture in BCB for the diagnosis of PJI. The pooled data were analysed by Meta-Disc software.ResultsFour studies with a total of 1071 patients were included in this meta-analysis. The summarized estimates showed that periprosthetic tissue culture in BCB may be of great value in PJI diagnosis with a pooled sensitivity of 0.70 (95% confidence interval [CI]; 0.66–0.75), specificity of 0.97 (95% CI: 0.95–0.98); positive likelihood ratio (PLR) of 20.98 (95% CI: 11.52–38.2); negative likelihood ratio (NLR) of 0.28 (95% CI: 0.20–0.40); and diagnostic odds ratio (DOR) of 92.26 (95% CI: 43.93–193.78).ConclusionsThe present meta-analysis showed that periprosthetic tissue in BCB improves the results of microorganism cultures, with a sensitivity of 70% and a specificity of 97%. However, more large-scale, well-performed studies are needed to verify our findings.
Highlights
The purpose of this meta-analysis was to evaluate the diagnostic accuracy of periprosthetic tissue culture in blood culture bottles (BCB) for periprosthetic joint infection (PJI)
Periprosthetic tissue culture is a common method for the diagnosis of PJI, which is included in the diagnostic criteria of the definition of the Infectious Diseases Society of America (IDSA), the Musculoskeletal Infection Society (MSIS) and the European Bone and Joint Infection Society (EBJIS) [6,7,8]
The procedure could be divided into two steps: 1. the intraoperative tissue is placed into the sterile container and transferred to the laboratory; 2. the periprosthetic tissue was homogenized in the biosafety laminar flow hood and inoculated into aerobic and anaerobic BCB [13, 14]
Summary
The purpose of this meta-analysis was to evaluate the diagnostic accuracy of periprosthetic tissue culture in blood culture bottles (BCB) for periprosthetic joint infection (PJI). The periprosthetic tissue was homogenized in the biosafety laminar flow hood and inoculated into aerobic and anaerobic BCB [13, 14]. It is unknown whether periprosthetic tissue culture in BCB can improve the diagnostic accuracy of PJI. We conducted this meta-analysis to evaluate periprosthetic tissue
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