Abstract
The rabbit myxoma and fibroma viruses, which are naturally very host-specific, prove to be much less so in tissue culture. Myxoma virus multiplies in vitro in various tissues of squirrel, guinea pig, rat, hamster and man and produces cytopathic effects in some of these. Ability to grow in rat tissues depends on the age of the animal furnishing the tissue. In the mouse, growth was demonstrated only in organ cultures of brain. Fibroma virus also multiplies in cultures of guinea pig, rat and human tissues.
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