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PDF Availablehttps://doi.org/10.1084/jem.20230419
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Cite Journal: Journal of Experimental Medicine |  Publication Date: Apr 18, 2023 |
 Citations: 4 |  License type: cc-by-nc-sa |
Affiliation: Immunity and Cancer, Inserm, Université Paris Cité
In this issue of JEM, Xiaozheng Xu et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20221391) report that the inhibitory protein CTLA4 internalizes in cis the B7 stimulatory molecules previously "gnawed" by T cells from antigen-presenting cells (APCs) and in doing so prevents stimulatory T-T interactions.
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