CTLA4 1661 A/G polymorphisms in North Indian Celiac disease patients. (47.21)

Abstract

Abstract Celiac disease or Gluten sensitive enteropathy is an immunomediated chronic small bowel disease caused by intolerance to prolamins,the proteic and alcohol soluble fractions of gluten,a major component of some of commonest cereal like wheat,rye and barley. Celiac Disease is an autoimmune disorder, characterised by villous atrophy of the small intestine, which results from a T-cell-mediated response to gluten-derived peptides. The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is involved in the regulation of T-cell activation and the CTLA4 1661 A/G polymorphism has been implicated in several autoimmune disorders, including celiac disease. The aim of this study is to determine the Genetic polymorphisms of the CTLA4 gene and genotyping of CTLA4-1661 A/G in celiac disease in the North Indian population. The 1661 A/G polymorphisms was genotyped in a case of 50 patients and 25 controls.The frequency of the 1661 G-allele was increased in celiac disease patients (p=0.013).The genotype distributions shows a significant difference between cases and controls.These results indicate the involvement of the CTLA4 gene in celiac disease development.The haplotype carrying the CTLA 4 1661 G allele was shown to be associated with disease. A larger patients and controls needs to be studied for further conclusive evidence. Statistical analysis was carried out using Microsoft Excel 2002 and SPSS 16 for Windows