Abstract
BackgroundThe results of genetic association studies regarding cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) polymorphisms and digestive system malignancies were controversial. The authors designed this meta-analysis to more precisely estimate relationships between CTLA-4 polymorphisms and digestive system malignancies by pooling the results of related studies.MethodsThe authors searched PubMed, Embase, Web of Science, and CNKI for eligible studies. Thirty-one eligible studies were pooled analyzed in this meta-analysis.ResultsThe pooled meta-analysis results showed that genetic distributions of rs231775, rs4553808, and rs733618 polymorphisms among patients with digestive system malignancies and controls differed significantly. Moreover, genotypic distribution differences were also observed for rs231775 polymorphism among patients with colorectal cancer/pancreatic cancer and controls, for rs4553808 and rs5742909 polymorphisms among patients with gastric cancer and controls, for rs3087243 polymorphism among patients with liver cancer and controls, and for rs733618 polymorphism among patients with colorectal cancer and controls in pooled meta-analyses.ConclusionsThis meta-analysis suggested that rs231775 polymorphism was associated with predisposition to colorectal cancer and pancreatic cancer, rs4553808 and rs5742909 polymorphisms were associated with predisposition to gastric cancer, rs3087243 polymorphism was associated with predisposition to liver cancer, and rs733618 polymorphism was associated with predisposition to colorectal cancer.
Highlights
The results of genetic association studies regarding cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) polymorphisms and digestive system malignancies were controversial
Twenty reviews were further excluded by the authors, and another three articles were excluded by the authors due to the lack of crucial data
Meta-analysis results of CTLA-4 polymorphisms and digestive system malignancies Twenty-eight studies were eligible for estimation of relationship between rs231775 polymorphism and digestive system malignancies, three studies were eligible for estimation of relationship between rs4553808 polymorphism and digestive system malignancies, six studies were eligible for estimation of relationship between rs5742909
Summary
The results of genetic association studies regarding cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) polymorphisms and digestive system malignancies were controversial. The authors designed this metaanalysis to more precisely estimate relationships between CTLA-4 polymorphisms and digestive system malignancies by pooling the results of related studies. Digestive system malignancies such as liver cancer, gastric cancer, and colorectal cancer are leading types of cancer among both males and females [1, 2]. If a polymorphism is of potential functional significance and can impact the gene expression or protein structure of CTLA-4, it is likely that this polymorphism might influence predisposition to
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