Abstract
PurposeTo explore the short-term efficacy and safety of CT-guided microwave ablation (MWA) for treating liver tumors near the diaphragm.ResultsThe complete response (CR) rate for CT-guided MWA through the lung was 94.7% (124/131). The incomplete response (ICR) rate was 5.3% (7/131), of which 6 patients with ICRs achieved CRs after MWA. The CR rate for Group I was higher than Group II (99.0% vs. 80.0%, P=0.001). The mean follow-up time was 11.2 ±7.50 months. The total local recurrence (LR) rate was 15.3% (20/131). The complication rate was 26.5%, and no severe complications were recorded. All complications were controllable and treatable. The incidence of diaphragmatic thickening during the MWA was 18.8% (P>0.05); the incidence of exudative changes inside the lungs was 6.8% (P>0.05).ConclusionsCT-guided MWA can detect changes in liver tissue, in the diaphragm and nearby lung tissues during the ablation process. It’s safe and effective to treat tumors close to the diaphragm by CT-guided MWA through the lung.MethodsCT-guided MWA was used on 131 tumors that were close to the diaphragm (distance between tumor and diaphragm ≤ 5 mm) in 117 patients with liver cancer. The tumors were divided into a < 3.0 cm group (Group I, n= 101) and a ≥ 3.0 cm group (Group II, n= 30) based on tumor diameters. The complications within 2 weeks following treatment were counted, and the safety and short-term efficacy of MWA were analyzed.
Highlights
Image-guided thermal ablation therapy has become the standard treatment for small liver tumors [1,2,3,4]
Ultrasoundguided percutaneous microwave ablation (MWA) has been widely applied for liver tumor treatment due to ease of operation and real-time monitoring; [5,6,7,8] because ultrasound is usually impacted by pulmonary gas and ribs, it is hard to have a clear display for liver tumors close to the diaphragm [9,10,11,12]
We showed that the efficacy of CT-guided MWA through the lung for liver tumors near the diaphragm was impacted by the diameter of the liver tumor
Summary
Image-guided thermal ablation therapy has become the standard treatment for small liver tumors [1,2,3,4]. Ultrasoundguided percutaneous microwave ablation (MWA) has been widely applied for liver tumor treatment due to ease of operation and real-time monitoring; [5,6,7,8] because ultrasound is usually impacted by pulmonary gas and ribs, it is hard to have a clear display for liver tumors close to the diaphragm [9,10,11,12]. For tumors close to the diaphragm, CT imaging has high resolution and accurate positioning [13, 14]. It is often necessary to puncture through the lung tissues to reach the liver tumors accurately. The therapeutic efficacy of MWA through lung tissues for treating liver tumors close to the diaphragm is a matter of debate. Whether or not there are more complications and whether or not the size of the tumors www.impactjournals.com/oncotarget
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