CT Features Associated With Risk of Infectious Complications Following Peripheral Endobronchial Ultrasound

Abstract

SESSION TITLE: Interventional Pulmonary Procedural Safety and Outcomes SESSION TYPE: Original Investigation Slide PRESENTED ON: Wednesday, October 26, 2016 at 02:45 PM - 04:15 PM PURPOSE: The reported incidence of peripheral endobronchial ultrasound (pEBUS) related infectious complications is below 1% although studies have never focused solely on them or reported their risk factors. The goal of this study is to describe our local pEBUS infectious complication rate and characterize patient, lesion and procedural factors associated with infectious complications. METHODS: All charts, computed tomographies and electronic records of patients who underwent a pEBUS at the Foothills Medical Center and South Health Campus Hospital in Calgary between May 1st 2014 and October 1st 2015 were reviewed. RESULTS: Two hundred pEBUS procedures were included in our study. The local infectious complication rate was 4.0% (8/200). Two lesion characteristics were more frequent in patients who suffered infectious complications: larger lesion diameter (p = 0.016) and lesion heterogeneity on imaging (p < 0.001) which is suggestive of areas of necrosis. In a multivariate analysis, only lesion heterogeneity was significantly associated with infectious complications (OR = 16.81 (2.96-95.53)). The rate of infectious complications in heterogeneous lesions was 6/29 (20.7%). CONCLUSIONS: The rate of infectious complications after pEBUS is elevated when biopsying heterogeneous lesions. This may not have previously been reported as studies of pEBUS focused on smaller and probably rarely necrotic lesions. CLINICAL IMPLICATIONS: Future studies of methods to prevent infections complications in pEBUS guided biopsies of heterogeneous lesions are warranted. DISCLOSURE: The following authors have nothing to disclose: Marc Fortin, Niloofar Taghizadeh, Alex Chee, Elaine Dumoulin, Christopher Hergott, Alain Tremblay, Paul MacEachern No Product/Research Disclosure Information