CT combined with serum CA19-9, CEA, CA125 in diagnosis of pancreatic cancer

Abstract

Objective To study the diagnostic value of CT combined with serum carbohydrate antigen19-9(CA19-9), carcinoembryonic antigen(CEA), carbohydrate antigen 125(CA125)in diagnosis of pancreatic cancer. Methods 68 patients with pancreatic occupying lesions were selected and they were divided into pancreatic cancer group(n=43)and non-pancreatic cancer group(n=25)according to pathological diagnosis. 34 cases from physical examination were set as the control group. All patients received CT examination and the consistency between CT diagnosis and pathological results was analyzed. Serum CA19-9, CEA, and CA125 were detected by chemiluminescence method. The sensitivity, specificity and accuracy of CT combined serum CA19-9, CEA, CA125 were analyzed. Results Among the 68 cases, 35 cases were pancreatic cancer diagnosed by CT, and the CT diagnosis was not ideal compared with pathological results. Nonparametric test found that serum CA19-9, CEA and CA125 in pancreatic cancer group were higher than those of the non-pancreatic cancer group and the control group, and the difference had statistical significance(P 0.05). Conclusion CT diagnosis had high susceptibility and low specificity, CT combined with serum CA19-9, CEA, and CA125 can improve accuracy of pancreatic cancer diagnosis. Key words: Computed tomography(CT); Carbohydrate antigen19-9; Carcinoembryonic antigen; Carbohydrate antigen 125; Pancreatic cancer