Abstract
Objective To investigate the clinical value of combined detection of serum carbohydrate antigen 199 (CA199), carbohydrate antigen 125 (CA125) and carcinoembryonic antigen (CEA) in the diagnosis of pancreatic cancer. Methods Fifty patients with pancreatic cancer diagnosed by pathological examination were selected as group A, 50 patients with benign pancreatic lesions were selected as group B and 50 cases without abnormality were selected as group C in the same period. All subjects underwent combined detection of serum CA199, CA125 and CEA. Results The levels of CA199, CA125 and CEA in group A were higher than those in group B and C, the differences were statistical significant (P<0.05). Specificities, sensitivity and accuracy of CA199, CA125, and CEA single tests were lower than those of combined detection (all P<0.05). Conclusions The specificity and sensitivity of combined detection of serum CA199, CA125 and CEA in the diagnosis of pancreatic cancer are higher than those in single tests, and the combined detection plays a guiding role in the evaluation of the patient’s condition and prognosis, which is worthy of clinical promotion. Key words: Pancreatic cancer; Carbohydrate antigen 199; Carbohydrate antigen 125; Carcinoembryonic antigen; Combined detection
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