Abstract
We report a novel method for crystallizing the metastable polymorph form II of acetaminophen by using a plastic ball during ultrasonic irradiation. The presence of a plastic ball during ultrasonic irradiation of aqueous acetaminophen solution effectively increased the probability and reduced the induction time of form II crystallization. This method facilitated both laboratory- and large-scale production of form II crystals. Our method has significant advantages for practical application of form II because it can reduce the time to production and enable large-scale production.
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