Abstract
Many polymorphs of KFA-1982, an orally active factor Xa (fXa) inhibitor, have been identified and their physicochemical properties have been investigated. Form B was selected as the oral API form because of its superior stability and solubility characteristics. Crystallization conditions for form B were thoroughly investigated including the role of water in hydrate formation and the use of antisolvents and supersaturation in polymorph control.
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