Abstract
In the title compounds, C14H17N5OS (I) and C13H15N5O2S (II), the dihedral angle between the pyrimidine and benzene rings is 58.64 (8)° in (I) and 78.33 (9)° in (II). In both compounds, there is an intra-molecular C-H⋯O hydrogen bond, and in (II) there is also an intra-molecular N-H⋯N hydrogen bond present. In the crystals of both compounds, a pair of N-H⋯N hydrogen bonds links the individual mol-ecules to form inversion dimers with R22(8) ring motifs. In (I), the dimers are linked by N-H⋯O and C-H⋯O hydrogen bonds, enclosing R21(14), R21(11) and R21(7) ring motifs, forming layers parallel to the (100) plane. There is also an N-H⋯π inter-action present within the layer. In (II), the inversion dimers are linked by N-H⋯O hydrogen bonds enclosing an R44(18) ring motif. The presence of N-H⋯O and C-H⋯O hydrogen bonds generate an R21(6) ring motif. The combination of these various hydrogen bonds results in the formation of layers parallel to the (1-11) plane.
Highlights
In the title compounds, C14H17N5OS (I) and C13H15N5O2S (II), the dihedral angle between the pyrimidine and benzene rings is 58.64 (8) in (I) and 78.33 (9) in (II)
In (I), the dimers are linked by N—HÁ Á ÁO and C—HÁ Á ÁO hydrogen bonds, enclosing R12(14), R12(11) and R12(7) ring motifs, forming layers parallel to the (100) plane
In (II), the inversion dimers are linked by N—HÁ Á ÁO hydrogen bonds enclosing an R44(18) ring motif
Summary
Diaminopyrimidine derivatives have been proved to be an important class of compounds because of their therapeutic and pharmacological properties. One such important property is its inhibition potency against cancer targets. Several diaminopyrimidine derivatives have shown good activity, efficiency against the malarial parasite Plasmodium falciparum K1 strain (Phuangsawai et al, 2016; Chiang et al, 2009). They act as calcium channel blocking agents (Manjula et al, 2004; Singh et al, 2009). Symmetry codes: (i) Àx þ 1; Ày þ 1; Àz þ 1; (ii) x þ 1; y þ 1; z; (iii) Àx þ 1; Ày þ 2; Àz þ 2
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