Abstract
The title tetra-nuclear copper complex, [Cu4Cl6O(C6H9N3O3)4] or [Cu4Cl6O-(MET)4] [MET is 1-(2-hy-droxy-eth-yl)-2-methyl-5-nitro-1H-imidazole or metronidazole], contains a tetra-hedral arrangement of copper(II) ions. Each copper atom is also linked to the other three copper atoms in the tetra-hedron via bridging chloride ions. A fifth coordination position on each metal atom is occupied by a nitro-gen atom of the monodentate MET ligand. The result is a distorted CuCl3NO trigonal-bipyramidal coordination polyhedron with the axial positions occupied by oxygen and nitro-gen atoms. The extended structure displays O-H⋯O hydrogen bonding, as well as unusual short O⋯N inter-actions [2.775 (4) Å] between the nitro groups of adjacent clusters that are oriented perpendicular to each other. The scattering contribution of disordered water and methanol solvent mol-ecules was removed using the SQUEEZE procedure [Spek (2015 ▸). Acta Cryst. C71, 9-16] in PLATON [Spek (2009 ▸). Acta Cryst. D65, 148-155].
Highlights
The title tetranuclear copper complex, [Cu4Cl6O(C6H9N3O3)4] or [Cu4Cl6O(MET)4] [MET is 1-(2-hydroxyethyl)-2-methyl-5-nitro-1H-imidazole or metronidazole], contains a tetrahedral arrangement of copper(II) ions
A fifth coordination position on each metal atom is occupied by a nitrogen atom of the monodentate MET ligand
The result is a distorted CuCl3NO trigonal–bipyramidal coordination polyhedron with the axial positions occupied by oxygen and nitrogen atoms
Summary
Metronidazole (C6H9N3O3; MET) is a medication that was discovered to be effective against both bacteria and parasites more than 50 years ago (Samuelson, 1999). MET is currently incorporated in the World Health Organization (WHO) list of essential medicines, i.e. medications that are considered to be effective and safe to meet the most important needs in a health system (WHO, 2015). Tetranuclear copper(II) compounds of the form [Cu4OX6L4] are relatively well known, with the first example described in 1996 (Bertrand & Kelley, 1966). In this regard, the structure of a [Cu4OX6L4] structure, where L = imidazole, has been previously described (Atria et al, 1999), a counterpart containing L = MET has not been reported. We describe the structure of a tetranuclear Cu–MET complex [Cu4Cl6O(MET)4] that is obtained by the reaction of anhydrous copper(I) chloride with MET in MeOH under aerobic conditions
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