Crystal structure of a DNA duplex containing four Ag(i) ions in consecutive dinuclear Ag(i)-mediated base pairs: 4-thiothymine-2Ag(i)-4-thiothymine.

Jiro Kondo,Toru Sugawara,Akira Ono,Hisao Saneyoshi

doi:10.1039/c7cc06153f

Abstract

Herein, we determined a high-resolution crystal structure of a B-form DNA duplex containing consecutive dinuclear metal ion-mediated base pairs, namely, 4-thiothymine-2Ag(i)-4-thiothymine (S-2Ag(i)-S), and four Ag(i) ions form a rectangular network and the distances between the Ag(i) ions are 2.8-3.2 Å, which may indicate the existence of metallophilic attractions.

Highlights

Crystal structure of a DNA duplex containing four Ag(I) ions in consecutive dinuclear Ag(I)-mediated base pairs: 4-thiothymine–2Ag(I)–4-thiothymine†
We determined a high-resolution crystal structure of a B-form DNA duplex containing consecutive dinuclear metal ionmediated base pairs, namely, 4-thiothymine–2Ag(I)–4-thiothymine (S–2Ag(I)–S), and four Ag(I) ions form a rectangular network and the distances between the Ag(I) ions are 2.8–3.2 Å, which may indicate the existence of metallophilic attractions
A similar metallophilic attraction has been observed in the above-mentioned crystals of the DNA duplex containing consecutive T–Hg(II)–T base pairs.6g A Hg(II)Á Á ÁHg(II) distance of 3.3 Å was indicative of a metallophilic attraction for Hg(II)

Summary

Introduction

Crystal structure of a DNA duplex containing four Ag(I) ions in consecutive dinuclear Ag(I)-mediated base pairs: 4-thiothymine–2Ag(I)–4-thiothymine†. We determined a high-resolution crystal structure of a B-form DNA duplex containing consecutive dinuclear metal ionmediated base pairs, namely, 4-thiothymine–2Ag(I)–4-thiothymine (S–2Ag(I)–S), and four Ag(I) ions form a rectangular network and the distances between the Ag(I) ions are 2.8–3.2 Å, which may indicate the existence of metallophilic attractions.

Results

Conclusion