Abstract
The emergence of novel coronaviruses requires new and innovative approaches in development of broad-spectrum antiviral therapeutics. Targeting and inhibiting replication machineries of pathogenic viruses is a proven and effective anti-viral strategy. Similar to other +RNA viruses, coronavirus genomic replication and transcription are moderated by an RNA replication-transcription complex (RTC) anchored in rearranged internal host membranes. The hallmark of coronavirus-induced membrane rearrangements is double-membrane vesicles (DMVs), named for their distinctive double-lipid bilayer.
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