Abstract
Crustaceans played a major role in establishing that gamma-aminobutyric acid (GABA) functioned as an inhibitory transmitter compound. In fact, it is now widely accepted that GABA is the major inhibitory transmitter compound in all animal species where it has been examined. The story of its acceptance as a neurotransmitter, however, is more interesting than that. GABA was first isolated from mammalian brains by 3 laboratories in 1950. Great excitement surrounded this discovery and many laboratories began exploring its function. This excitement peaked in two large international congresses in the United States at the end of the first decade of study at which a consensus of major figures in the field was that GABA was not a transmitter compound. How could this have happened?
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