Abstract
Acquired stress resistance is the result of mild stress causing the acquisition of resistance to severe stress of the same or a different type. The mechanism of “same-stress” resistance (resistance to a second, strong stress after mild primary stress of the same type) probably depends on the activation of defense and repair mechanisms specific for a particular type of stress, while cross-stress resistance (i.e., resistance to a second, strong stress after a different type of mild primary stress) is the effect of activation of both a specific and general stress response program, which in Saccharomyces cerevisiae yeast is known as the environmental stress response (ESR). Advancements in research techniques have made it possible to study the mechanism of cross-stress resistance at various levels of cellular organization: stress signal transduction pathways, regulation of gene expression, and transcription or translation processes. As a result of this type of research, views on the cross-stress protection mechanism have been reconsidered. It was originally thought that cross-stress resistance, irrespective of the nature of the two stresses, was determined by universal mechanisms, i.e., the same mechanisms within the general stress response. They are now believed to be more specific and strictly dependent on the features of the first stress.
Highlights
Acquired stress resistance is the result of mild stress causing the acquisition of resistance to severe stress of the same or a different type
This study showed that the roles of Msn2p and Msn4p in the cross-stress resistance mechanism were not entirely redundant
In the 1980s and 1990s, same-stress resistance and cross-stress resistance were already being treated as an inherent attribute of the response of S. cerevisiae yeast to various types of environmental stress
Summary
Cross-stress resistance in Saccharomyces cerevisiae yeast—new insight into an old phenomenon. This article is published with open access at Springerlink.com
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