Year-end Sale % OFF 
Abstract
To determine the relevance of epiretinal membranes (ERMs) in primary open-angle glaucoma (POAG) and potential risk for glaucoma severity. Sixty eyes of 30 patients with POAG who had a unilateral ERM were analyzed; 60 nonglaucomatous eyes of 30 patients with a unilateral ERM also were recruited in this institutional cross-sectional study. Patients underwent swept-source (SS) optical coherence tomography (OCT) imaging and visual field testing. Intraindividual differences in the SS-OCT retinal nerve fiber layer (RNFL) disc cupping area measurements and visual field outcomes were analyzed in the two groups. In patients with POAG, the mean circumpapillary RNFL thickness in the eyes with an ERM was 75.6 ± 16.5 μm superiorly and 71.8 ± 26.0 inferiorly compared with the fellow eyes without an ERM (87.2 ± 23.6 μm, P = 0.0061 and 81.3 ± 27.7 μm, P = 0.034, respectively). The areas of disc cupping and cup-to-disc ratio seen on OCT horizontal and vertical B-scans were larger in eyes with an ERM than in the fellow eyes without ERM (P = 0.0004 and P = 0.0011, respectively). The average mean deviations were -11.6 ± 7.5 dB in the ERM group and -8.19 ± 6.4 dB in the group with no ERM (P = 0.029). Eyes with an ERM received more antiglaucoma eye drops (P = 0.018). Those differences were not seen between eyes with an ERM or fellow eyes in patients without glaucoma. The presence of an ERM can be a potential risk factor for unilateral severity in eyes with POAG.
Highlights
The areas of disc cupping and cup-to-disc ratio seen on optical coherence tomography (OCT) horizontal and vertical B-scans were larger in eyes with an epiretinal membranes (ERMs) than in the fellow eyes without ERM (P 1⁄4 0.0004 and P 1⁄4 0.0011, respectively)
Eyes with an ERM received more antiglaucoma eye drops (P 1⁄4 0.018). Those differences were not seen between eyes with an ERM or fellow eyes in patients without glaucoma
Multiple groups have reported peripapillary retinoschisis associated with transient increases in retinal nerve fiber layer (RNFL) thickness in glaucomatous eyes as determined by OCT.[7,8]
Summary
Sixty eyes of 30 patients with POAG who had a unilateral ERM were analyzed; 60 nonglaucomatous eyes of 30 patients with a unilateral ERM were recruited in this institutional cross-sectional study. Patients underwent swept-source (SS) optical coherence tomography (OCT) imaging and visual field testing. History of retinal detachment Intermediate or advanced age-related macular degeneration History of choroidal neovascularization of any etiology Central serous chorioretinopathy Proliferative diabetic retinopathy Nonproliferative diabetic retinopathy with a history of clinically significant diabetic macular edema Tractional and degenerative lamellar macular holes History of central or branch retinal vein occlusion and central or branch retinal artery occlusion History of inflammatory eye disorders History of endophthalmitis or any other intraocular infection Retinal dystrophies Unreliable visual field tests Poor-quality SS-OCT scans. The study was a retrospective consecutive case series of POAG associated with unilateral ERMs in patients who visited the Department of Ophthalmology of Osaka University Hospital from October 2014 through November 2017. We retrospectively reviewed the medical records of 348 consecutive patients with bilateral OAG, including 30 patients with a unilateral ERM during the follow-up glaucoma evaluations. Age-matched subjects with an ERM were recruited from among the patients in the hospital if they had an IOP of 21 mm Hg or lower and an optic nerve head (ONH) that appeared normal on a fundus examination
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
