Abstract
The purpose of this study was to translate the English bone tumour DUX (Bt-DUX-Eng) questionnaire for lower extremity bone tumour patients, a disease-specific quality of life (QoL) instrument, into Italian and then examine the validity of the Italian version of Bt-DUX (Bt-DUX-It). The adaptation and translation process included forward translation, back-translation, and a review of the back-translation by an expert committee. The Bt-DUX-It was validated in a sample of adolescents treated for lower extremity osteosarcoma in Italy. Assessments included the Bt-DUX, the Toronto Extremity Salvage Score (TESS), and the European Organization for Research and Treatment Core Quality of Life Questionnaire of Cancer Patients (EORTC QLQ-C30). Fifty-one patients with a median age of 20 years (range: 15–25) completed the questionnaires. The mean Bt-DUX score was 70 (range: 16.30–100). The internal consistency of the overall score and that of the Bt-DUX-It was good: Cronbach’s α was 0.95. Spearman’s correlation coefficient between the Bt-DUX (total and domain scores) and EORTC QLQ C30 and TESS were overall moderate to good, reaching a p-value <0.01 in all cases. The Bt-DUX-It version is a useful tool for measuring QoL in patients with bone tumour and has similar internal consistency, construct validity, and discrimination as those of the Dutch and English versions.
Highlights
Malignant bone tumours like osteosarcoma and Ewing sarcoma mostly appear in the teenage years and in the long bones of the lower extremities
Surgical techniques, and the young age of patients affected by this disease have over time attracted growing interest in the functional outcome and quality of life (QoL) after surgery [2,3,4,5]
The Bt-DUX questionnaire was constructed as a disease-specific questionnaire, modelled on the generic DUX 25 QoL questionnaire
Summary
Malignant bone tumours like osteosarcoma and Ewing sarcoma mostly appear in the teenage years and in the long bones of the lower extremities. Most studies on the outcome of surgery have so far mainly focused on basic daily activities or have used generic tools for QoL [7,10,11] These tools fail to take into account a number of relevant issues, such as the patient’s own assessment of the cosmetic, functional, and emotional impact of the disease and its surgical treatment. These issues are included in a recently developed questionnaire DUX for bone tumours in children and adolescents (Bt-DUX) [12]. The Bt-DUX questionnaire was constructed as a disease-specific questionnaire, modelled on the generic DUX 25 QoL questionnaire
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