Abstract
Recent studies have demonstrated that the outcome of critically ill patients is better in females than in males. Although estrogen has been shown to be critically involved in regulation of immune responses, the detailed mechanism(s) underlying such gender differences has yet to be fully understood. Since proinflammation plays a critical role in the development of the organ dysfunction seen in such critically ill patients, estrogen might show any anti-inflammatory effects to attenuate such inflammatory responses. We previously reported that capsaicin-sensitive sensory neurons (CSSN), nociceptive neurons, play an important role in attenuating inflammatory responses by releasing calcitonin gene-related peptide (CGRP), which promotes the endothelial production of prostacyclin, one of the anti-inflammatory prostaglandins [1]. Since estrogen increases the synthesis of nerve growth factor, which increases the CGRP production, estrogen might attenuate inflammatory responses by promoting CGRP release from CSSN. We examined this possibility in the present study.
Highlights
Activation of the HPA axis occurs in order to control potentially deleterious effects of systemic inflammation during sepsis
Arterial blood gases (ABGs) are the immediate, easiest, most reliable and cost effective bedside method of assessing an unstable patient. It portrays an array of functional reserves from the lungs to the kidneys and the blood cells in between
A significant benefit was demonstrated with amikacin/ceftazidime versus pefloxacin/ceftazidime, risk difference (RD) = 20%, in a single low-quality trial
Summary
Activation of the HPA axis occurs in order to control potentially deleterious effects of systemic inflammation during sepsis. The aim of the study was to evaluate the effects of PEEP on intrathoracic blood volumes and cardiac function measured by the COLD system in ARDS patients. The objective was to identify risk factors and outcome of pregnant women who required intensive care This pilot study aims to find stress (S) and other personality traits (physical symptoms [PS], anger [A]) among the ICU staff, and any existing correlation between them and length of working time (LWT) in the ICU and with educational level (EDL). The role of Drotrecogin alfa (activated) (recombinant human activated protein C [rhAPC]) in modulating microvascular coagulation through the inhibition of thrombin generation has been well studied in experimental and clinical settings of severe sepsis, little is known about its direct anti-inflammatory effects on vascular endothelial cells. The aim is to determine whether an effective lifestyle adaptation program post CABG could enhance the quality of life of the CABG patient
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