Abstract
Background and Aims : Endoglin (Eng), the TGF-β co-receptor, plays an important role in endothelial dysfunction and TRC105 is an antibody that blocks Eng and its signaling. Here we have investigated for the first time, the TRC105 effects on the Eng expression, signaling, and function in endothelial dysfunction induced by hypercholesterolemia (simulated by 7-ketocholesterol [7K], the most common oxysterol in plasma) and hyperglycemia (simulated by high glucose [HG]).
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