Abstract
(1) Background: The tissue engineering field has been working to find biomaterials that mimic the biological properties of autogenous bone grafts. (2) Aim: To evaluate the osteoconduction potential of injectable calcium phosphate cement implanted in critical defects in rat calvaria. (3) Methods: In the calvarial bone of 36 rats, 7-mm diameter critical size defects were performed. Afterwards, the animals were randomly divided into three groups according to filler material: a blood clot group (BC), blood clot membrane group (BCM), and an injectable β-tricalcium phosphate group (HBS) cement group. After periods of 30 and 60 days, the animals were euthanized, the calvaria was isolated, and submitted to a decalcification process for later blades confection. Qualitative and quantitative analysis of the neoformed bone tissue were conducted, and histometric data were statistically analyzed. (4) Results: Sixty days post-surgery, the percentages of neoformed bone were 10.67 ± 5.57 in group BC, 16.71 ± 5.0 in group BCM, and 55.11 ± 13.20 in group HBS. The bone formation values in group HBS were significantly higher (p < 0.05) than in groups BC and BCM. (5) Conclusions: Based on these results, it can be concluded that injectable calcium phosphate cement is an osteoconductive material that can be used to fill bone cavities.
Highlights
IntroductionPeople have been concerned with restoring or replacing damaged parts of bone tissue
Since ancient times, people have been concerned with restoring or replacing damaged parts of bone tissue
(2) Aim: To evaluate the osteoconduction potential of injectable calcium phosphate cement implanted in critical defects in rat calvaria
Summary
People have been concerned with restoring or replacing damaged parts of bone tissue. Due to trauma and disease, millions of patients worldwide require bone grafting procedures every year. Autogenous bone grafts have disadvantages like the need for surgical procedures in donor areas, which increase the risks of lesions, infections, hemorrhage, postoperative trauma, morbidity, and poor bone quality and availability [3]. Such disadvantages have been driving researchers to search for a biomaterial that replaces autogenous bone in shape and function [4], preferably synthetic, because it would be free of quantity limitations and contamination risks [5,6]
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