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PDF Availablehttps://doi.org/10.1016/j.jaci.2019.12.913
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Cite Publication Date: Jan 15, 2020 | |
 Citations: 9 |
Summary CRISPR-Cas9 engineered CYBBko THP-1 cell lines display an inflammatory profile with increased IL-1β, IL-6 and TNF-α secretion as consequence of NADPH-induced ROS deficiency. This phenotype is reminiscent of the one observed in phagocytes from CGD patients.
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