Abstract
Creatine is one of the most sought after supplements by those who perform physical activities, as it enables strength gain, muscle recovery and hypertrophy. Patients with chronic kidney disease (CKD) have greater creatine losses and impairment in the endogenous synthesis process, since the first and limiting stage occurs in the kidney. This study is a literature review and its main objective is to investigate the possible adverse effects of chronic creatine use on renal function. Creatine is widely used as a supplement to improve sports performance, but there are concerns about its potential adverse effects. Previous studies have been reviewed to address the main factors contributing to the divergence in conclusions. The results indicate that while creatine is generally safe for healthy people, there are reported cases of kidney failure in genetically predisposed individuals.
Published Version
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