Cp2TiCl2-catalyzed synthesis of tetraalkyl-substituted pyrazines by the reaction of nitriles with EtAlCl2 and Mg

Mariya G Shaibakova,Nikita A Rikhter,Leisan K Dil'Mukhametova,Ilfir R Ramazanov

doi:10.1016/j.mencom.2023.02.031

Cp2TiCl2-catalyzed synthesis of tetraalkyl-substituted pyrazines by the reaction of nitriles with EtAlCl2 and Mg

Mariya G Shaibakova, Nikita A Rikhter + Show 2 more

https://doi.org/10.1016/j.mencom.2023.02.031

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Journal: Mendeleev Communications

Publication Date: Mar 1, 2023

Affiliation: Ufa Institute of Chemistry

#Reaction Of Nitriles #Presence Of Mg + Show 3 more

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Abstract

Tetraalkyl-substituted pyrazines were obtained by the multicomponent reaction of aliphatic linear nitriles with EtAlCl2 in the presence of Mg and Cp2TiCl2 catalyst in 60–91% yields. The same processing of isobutyronitrile gave 2,4,5-triisopropyl-1H-imidazole in 56% yield.

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